Secondary metabolism and phylogeny

Secondary metabolism has proven essential to the speciation of Aspergillus fungi. Here we present an analysis tool to investigate families of secondary metabolism gene clusters and how they are shared across phylogenetic distances.

ANALYSIS – secondary metabolism and phylogenyaspmineSynteny (1)

  • [Bushley2010] Bushley, K., and Turgeon, G. (2010) Phylogenomics reveal subfamilies of fungal nonribosomal peptide synthetases and their evolutionary relationships, Bmc Evol Biol, bmc 10.
  • [Fox2008] Fox, E., and Howlett, B. (2008) Secondary metabolism: regulation and role in fungal biology, Curr Opin Microbiol, sciencedirect 11.
  • [Hoffmeister2007] Hoffmeister, D., and Keller, N. (2006) Natural products of filamentous fungi: enzymes, genes, and their regulation, Nat Prod Rep, rsc 24.
  • [Khaldi2009] Khaldi, N., Seifuddin, F. T., Turner, G., Haft, D., Nierman, W. C., Wolfe, K. H., and Fedorova, N. D. (2010) SMURF: genomic mapping of fungal secondary metabolite clusters, Fungal genetics and biology : FG & B, Fungal genetics and biology : FG & B 47, 736–741
  • [Medema2011] Medema, M. H., Blin, K., Cimermancic, P., de Jager, V., Zakrzewski, P., Fischbach, M., Weber, T., Takano, E., and Breitling, R. (2011) AntiSMASH: Rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences, Nucleic Acids Research, Nucleic Acids Research 39, 339–346.
  • [Osbourn2010] Osbourn, A. (2010) Secondary metabolic gene clusters: evolutionary toolkits for chemical innovation., Trends in genetics : TIG 26, 449–57.
Advertisements

Comments are closed.

Create a website or blog at WordPress.com

Up ↑